Medical Air: What you don’t know won’t hurt you, but what about your patients?
1Vice President Medical Gases, VitalAire Canada Inc. Mississauga, Ont long-standing associate member of CSA Z251.20, technical sub-committee responsible for development of CSA Medical Gas Standards
2Manager of Clinical Affairs, VitalAire Canada Inc - Air Liquide Healthcare, Blainville, QC, Canada; Board member of CSRT and FCSRT
Correspondence: Patricia-Ann Therriault, Vitalaire Canada Inc. Mississauga, Ont, E-mail: email@example.com
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Can J Respir Ther 2018;54(2):48–49
Medical Air is dispensed daily from thousands of wall outlets in Canadian hospitals. In locations treating high acuity respiratory patients, the use of Medical Air rivals—and often eclipses—oxygen . Most hospitals with centrally piped Medical Air make the product onsite by compressing outdoor air .
As an RRT responsible for ventilation, high flow therapy, isolette environment control, or aerosol therapies, have you ever wondered about the quality of air issued from the wall outlets? Health Canada deems Medical Air as a Schedule E drug , and the Canadian Building Code mandates that when made onsite at hospitals, “the health care facility shall ensure that the product produced by the Medical Air supply system and delivered to the pipeline distribution system meets the specifications for Medical Air USP or another monograph(s) as specified by the health care facility formulary” (CAN/CSA Z7396.1–17, 188.8.131.52.3) .
A report produced by Air Liquide Healthcare  describes findings from Medical Air quality sampling that began in February 2014 and now has over 60,000,000 chemical analysis data points collected from Medical Air source systems at major urban and remote rural sites. Through this data, we've learned that every site studied experienced USP formula breaches. Most breaches are related to short-term events such as a helicopter landing, whereas others that are linked to environmental conditions, such as forest fires, persist for weeks. Sampled product has revealed CO levels above 50 ppm; more than five times the USP limit. And elevated levels of CO2, often exceeding the USP limit by a factor of two, is by far the most common problem.
We have found that as we share evidence of quality problems with RRTs across the country, local stories of potential Medical Air quality breaches come to the surface. Staff from two sites with a level III NICU reported worrisome CO levels in patient arterial blood gas samples. In both cases, site personnel deemed the most plausible root cause to be high CO in centrally piped Medical Air. At sites with measured CO breaches, the root causes range from hospital boiler exhaust to idling diesel engine emissions that contaminate the air purity.
With CO2 being the most prevalent off-specification contaminant, special attention must be paid to this known asphyxiant. Exposure to concentrations of >8% or more can cause death, unconsciousness, or convulsions . In terms of human physiology, we also know that normal CO2 levels in blood are essential to pH regulation and alveolar gas exchange. From a therapeutic perspective, in small controlled doses CO2 is an effective respiratory stimulant.
What we did not know until recently is that typical dryers used in hospital production of Medical Air are catching and releasing CO2 boluses into the pipeline . Figure 1 illustrates the variability of CO2 measured through one day at a major urban facility with a mid-day bolus release .
Knowing that CO2 is a “sticky” molecule (i.e., higher density than oxygen or nitrogen), we wondered how far a bolus could travel intact through a pipeline. Further study confirmed a 1 L release of CO2 can travel beyond a kilometre within a half-inch copper pipeline and cause an oxygen deficient atmosphere (i.e., O2 < 18% volume/volume percent) upon exiting. The bolus depicted in Figure 1 occurred after a brief shut-down and restart of the Medical Air plant. The sudden spike in CO2 lasted a few minutes and very likely resulted in oxygen deficient Medical Air at one or more wall outlets.
With consideration of this emerging evidence, the authors of Canada’s medical gas piping regulation published a new requirement in 2017 (CSA Z7396.1, s184.108.40.206.5 (b)) that involves clinicians . Moving forward, when a Medical Air system is installed, modified, or replaced at a health care facility, a quality risk assessment must be performed to determine that the frequency of quality monitoring and control is appropriate, given the site-specific therapeutic applications involving Medical Air. Additionally, clinicians must take part in the assessment and be prepared to answer questions like:
- Are short-term bursts of oxygen deficient and CO2-laden Medical Air safe for your patients?
- Should your site’s Medical Air production system be designed to automatically prevent high levels of CO or CO2 from entering the pipeline?
In conclusion, Medical Air is a therapeutic product made on-site by most hospitals. Like all drugs, it must follow a formula. Canadian hospitals can choose the USP formula, or devise their own. USP lists six contaminants: carbon monoxide, carbon dioxide, humidity, nitric oxide, nitrogen dioxide, and sulphur dioxide. Are there other contaminants you would like measured and controlled, such as ozone? And what threshold limits for each contaminant make sense for your patients ?
The evidence and regulations say it’s time for Respiratory Therapists to know and enforce the Medical Air formula at their hospitals!
|1.||Allen M, Edwards P. Medical air white paper. 2014. Available at: www.aeralin.com data on file.|
|2.||Health Canada Drug Data Base. Available at: https://health-products.canada.ca/dpd-bdpp/dispatch-repartition.do|
|3.||Canadian Standards Association. 2017. Z7396.1-17 – Medical gas pipeline systems – Part 1: Pipelines for medical gases, medical vacuum, medical support gases, and anaesthetic gas scavenging systems. (CAN/CSA Z7396.1). Available at: http://shop.csa.ca/en/canada/perioperative-safety/z73961-17/invt/27025122017|
|4.||Medical air: A risk assessment, Rev 1.0; August 2017. Available at: https://www.vitalaire.com/wp-content/uploads/2018/03/Medical-Air-Risk-Assessment-rev-2.1-Final.pdf|
|5.||Edwards P, Therriault P, Katz I. Onsite production of medical air: Is purity a problem? Available at: https://rdcu.be/NB81|
|6.||Rice S. Human health risk assessment of CO2: Survivors of acute high-level exposure and populations sensitive to prolonged low-level exposure. 2004.|
|7.||Edwards P., Assessing the quality of on site medical air. IFHE Digest 2018|